Chelsea vs Norwich
After not being at the races at the weekend, Chelsea will once look to gain pole position in the race for 3rd place and with a now relegated Norwich providing the latest opposition, it should mean business as usual for Frank Lampard's men.
Norwich have now lost their last seven league outings and it is beginning to be more akin to men versus boys at present, as the Canaries are singing their way back to the EFL Championship.
Prediction: Chelsea 2-0 Norwich
Manchester City vs Bournemouth
Last weekend saw an emphatic win for Manchester City and with Pep Guardiola's men putting five past Brighton on Saturday, they will look to carry a head of steam into their F.A. Cup Semi-final clash with Arsenal.
Standing in their way of building that very momentum, are a Bournemouth side who picked up a huge win on Sunday and the Cherries will have to provide something similar at the Etihad, in a bid to aid their survival hopes.
Prediction: Manchester City 3-0 Bournemouth
Newcastle vs Tottenham
Newcastle have failed to win any of their last three league outings and in doing so, have only picked up a point for their efforts. However, that run of form does not mean there is a crisis on Tyneside, as the Magpies are already safe from the threat of relegation.
Wednesday night sees them play host to a Tottenham side who have just reignited their hopes of earning a Europa League place, with an important win over their biggest rivals Arsenal on Sunday.
Prediction: Newcastle 0-2 Tottenham
Arsenal vs Liverpool
That defeat to Tottenham, has seen Mikel Arteta's men slip to 9th in the Premier League table and with three games to go, time is running out for the Gunners to book a berth in next season's Europa League competition.
While life gets no easier in midweek, as champions Liverpool come to town and they will have a point to prove after dropping two of them to Burnley at the weekend.
Prediction: Arsenal 1-2 Liverpool
Everton vs Aston Villa
Everton are now in nothing more than extended pre-season mode and all Carlo Ancelotti can do now, is put his collection of players through the ringer and work out, which ones he wants to usher out of the Goodison Park door in the summer.
Which could mean good news for Aston Villa and with them picking up a huge win against Crystal Palace on Sunday, they will look to pounce on another team who is all but on the beach.
Prediction: Everton 1-2 Aston Villa
Leicester vs Sheffield United
Are Leicester collapsing at just the wrong time? On the evidence of their 4-1 defeat to Bournemouth and their subsequent second half performance, it does seem as if the Foxes are perhaps losing their bite at the worst point of the season.
Which means the visit of Sheffield United will not be an easy one and with the Blades hoping for a place in Europe next season, they may just scupper the hopes of Leicester with a win in midweek.
Prediction: Leicester 0-1 Sheffield United
Crystal Palace vs Manchester United
Crystal Palace could not be anymore on the beach right now and it is a surprise Roy Hodgson is not wearing a Hawaiian shirt and sunglasses on the touchline, as the South London outfit have lost each of their last five league outings.
They go up against a Manchester United side, who if you whisper it quietly, are actually becoming quite fun to watch and if it all clicks in attack again, another important win should be on the agenda.
Prediction: Crystal Palace 0-2 Manchester United
Southampton vs Brighton
Southampton have very little to play for, bar perhaps Premier League prize money and therefore the focus will be on whether Danny Ings can scoop the Golden Boot at the end of the season, as the Saints forward looks to stay on the tail of current top scorer Jamie Vardy.
The next defence he will look to torture is Brighton's and with them not quite safe and the improvement of teams below them, another point or two may be needed for Graham Potter's men.
Prediction: Southampton 1-1 Brighton
West Ham vs Watford
A relegation ‘six-pointer' ends the gameweek and there is no doubt both West Ham and Watford will be looking at this encounter as a must win and if either outfit does, that will likely be the performance that keeps them in the division.
The Hammers and the Hornets both won at the weekend and were it not for Aston Villa and Bournemouth also winning their games, they could have breathed a lot easier going into this one. Life's never easy at the botttom.
Prediction: West Ham 2-1 Watford