Leicester vs Liverpool
Leicester's stuttering form continued at the weekend, as they played out a bore draw with Wolves at Molineux and with their buffer between themselves and an exit out of the top four slightly eroding, manager Brendan Rodgers will have to hope the same collapse of last season does not happen again.
While this weekend could be pivotal in the race for the top four, as they play host to Liverpool and after shipping four to Manchester City last Sunday, Jurgen Klopp and his players will have to do some soul searching.
Prediction: Liverpool 1-2 Leicester
Crystal Palace vs Burnley
Crystal Palace's mini revival came to an end on Monday, as Roy Hodgson's men lost away at Leeds and after a relatively meek showing at Elland Road, the Eagles will look to soar once more this weekend.
Standing in the way of such aspirations are Burnley and with no win in their last three league outings, victory in the capital on Saturday would certainly be welcomed by manager Sean Dyche.
Prediction: Crystal Palace 1-1 Burnley
Manchester City vs Tottenham
Are Manchester City the champions elect? On the evidence of what we've seen lately, you would certainly think so and after recording a tenth straight league success last weekend, the only team that seems capable of stopping them are themselves.
This Saturday sees them play host to Tottenham and although a win against West Brom would be welcomed, the fear is that their poor recent form has already caused irreversible top four damage.
Prediction: Manchester City 2-0 Tottenham
Brighton vs Aston Villa
Brighton's recent run of results has seen them pull further clear of the relegation zone and although the battle to avoid the drop is far from finished, manager Graham Potter and his players will have gained a huge amount of confidence as of late.
While it is confidence that will be in huge supply within the Aston Villa camp and after getting the better of Arsenal last weekend, manager Dean Smith will be hoping for more of the same this Saturday.
Prediction: Brighton 1-2 Aston Villa
Southampton vs Wolves
Southampton have certainly gone off the boil as of late and after suffering defeat to Newcastle last weekend, the Saints have lost their last five league outings. While it is this run of form, that has all but scuppered their hopes of European football next season.
Another team that had European aspirations at the start of the season were Wolves and although they are unbeaten in their last two, it's the wretched run beforehand which leaves them mid-table.
Prediction: Southampton 1-1 Wolves
West Brom vs Manchester United
Big Sam's toughest ever task is looking tougher by the week and after suffering defeat to Tottenham on Sunday, West Brom now find themselves an almost insurmountable 11 points from the promised land of 17th.
This weekend sees Allardyce and his players welcome Manchester United to the Hawthorns and with just one win in their last four, the dream of becoming champions is now looking somewhat distant.
Prediction: West Brom 0-2 Manchester United
Arsenal vs Leeds
After an impressive unbeaten run pulled Arsenal clear of the relegation zone, there is a feeling that the Gunners have reverted to type and this can be signified, by their failure to win any of their last three league outings.
A run that has seen them slip back into the bottom half of the table and moving up at their expense, are their weekend opponents Leeds, as Marcelo Bielsa's men start the weekend lying in tenth place.
Prediction: Arsenal 1-2 Leeds
Everton vs Fulham
Everton were responsible for the highest drama last weekend, as Dominic Calvert-Lewin snatched a late equaliser at Old Trafford and after that 3-3 draw, Carlo Ancelotti will hope that can be the springboard for an extended run of positive results.
Which is something that opponents Fulham desperately need and although manager Scott Parker oversaw another draw last weekend, the rate of progress is simply not enough at Craven Cottage.
Prediction: Everton 2-0 Fulham
West Ham vs Sheffield United
The bad news for West Ham, is that Tomas Soucek was sent off last weekend against Fulham. The good news for West Ham, is that the Czech midfielder had his red card rescinded on Monday and is once again available for selection.
Which means it is good news for David Moyes and bad news for his counterpart Chris Wilder on Monday night, as the latter must now devise a winning plan against a stronger Hammers outfit.
Prediction: West Ham 2-0 Sheffield United
Chelsea vs Newcastle
The Thomas Tuchel era at Chelsea is really picking up pace now and with 10 points earned from the first 12 on offer, it looks as if the Blues have also found an ignition spark regarding their hopes for a top four finish.
A spark they hope will turn into flames on Monday, as they play host to Newcastle and even after a resurgence under Steve Bruce, victory in the capital may prove to be too big an ask for the Magpies.
Prediction: Chelsea 3-0 Newcastle
Burnley vs Fulham
Midweek sees us treated to another relegation 'six-pointer', as Burnley play host to Fulham and after the Clarets earned an impressive 3-0 win on Saturday, they will look to build on their impressive performance over Crystal Palace.
Then again, opponents Fulham impressed at the weekend after getting the better of Everton at Goodison Park, it has just allowed Scott Parker and his players the chance to dream of staying up at the end of the season.
Prediction: Burnley 1-2 Fulham
Everton vs Manchester City
With two games in hand, Everton are certainly the wild cards in the race for the top four and although their position looks favourable now, it could have even better.
The Toffees will look to bounce back after a disappointing performance against Fulham and it is task that will be rather hard, as they play host to a rather high-flying Manchester City.
Prediction: Everton 1-3 Manchester City