Norwich vs West Ham
While although Norwich are not yet mathematically relegated, the Canaries do seem to be resigned to their fate and with just four games of the season left to play, it does look as if time has almost expired for Daniel Farke's men.
Failure to get the better of West Ham on Saturday will mean relegation and if the Hammers fail to pick up all three points, it will be a huge opportunity missed in terms of their own survival hopes.
Prediction: Norwich 0-2 West Ham
Watford vs Newcastle
Watford are another team that are just on the right side of the relegation dotted line and it is perhaps the inability of other outfits, which has meant Nigel Pearson's men are keeping their heads above the water.
This weekend sees them play host to a Newcastle side who were thumped by Manchester City last time around and Watford will hope that the Magpies have all but stuck a pin in their season.
Prediction Watford 1-0 Newcastle
Liverpool vs Burnley
After getting the better of Brighton in midweek, it seems as if the Liverpool juggernaut is showing no signs of slowing down and with a record points tally also up for grabs, Jurgen Klopp's men will be looking to earn their 31st Premier League win of the season.
To do so, they will need to get the better of a Burnley side who themselves won in midweek and after his efforts on Wednesday, goalkeeper Nick Pope may prove to have another busy outing.
Prediction: Liverpool 2-0 Burnley
Sheffield United vs Chelsea
Some quarters were writing off Sheffield United just a couple of weeks ago (yours truly) but recent results have put a lot of egg on a lot of faces and with a Europa League berth still on the table, Chris Wilder's men are not ready to fold just yet.
Which could provide a stern test for Chelsea this weekend and with the Blues now up to third in the table, they will look to further solidify their hopes of a top four finish at the end of the season.
Prediction: Sheffield United 1-1 Chelsea
Brighton vs Manchester City
Credit must go to Graham Potter for setting up his players against Liverpool and although going on the front foot must be admired, it was a decision that proved to be suicidal. With that in mind, the former Swansea boss will have to decide if its more of the same this weekend.
That's because the fixture list is no kinder, as Manchester City come to the AMEX and after winning the title here last season, the former champions will have to make do with second instead.
Prediction: Brighton 0-3 Manchester City
Wolves vs Everton
Wolves' hope of a top-four finish has just started to lose steam over the past week and although a Europa League berth is on the table still, it may make more sense in them trying to actually win this season's edition of the competition instead.
Next up is the visit of Everton and although the Toffees have looked good under new manager Carlo Ancelotti, inconsistent results are certainly proving to be their Achilles heel at present.
Prediction: Wolves 2-1 Everton
Aston Villa vs Crystal Palace
It's now no win in 10 for Aston Villa and after a damaging defeat to Manchester United on Thursday, their performance suggests that Dean Smith is running out of ideas and his demeanour suggests, that he is very much aware of this fact.
Thankfully, Crystal Palace are proving to be the ideal tonic as of late and if anyone signifies a team being on the beach it is, they. The question is whether Villa can take advantage of such lax effort?
Prediction: Aston Villa 2-1 Crystal Palace
Tottenham vs Arsenal
Usually this is a fixture that is building up nicely by this point and is arguably the best derby clash in the Premier League. However, with the malaise and transition that both Tottenham and Arsenal are currently going through, there is much less of a fever brewing this time around.
Tottenham have stunk out the joint in their last three outings, while Arsenal are finding their feet at just the right time and they look the better placed side to earn themselves a Europa League berth.
Prediction: Tottenham 1-1 Arsenal
Bournemouth vs Leicester
How big could Bournemouth's point against Tottenham be in the long run? Not big enough if they fail to add more and with Leicester coming to the Vitality Stadium this Sunday, its going to need another huge performance from Eddie Howe's men.
However, Leicester are not in the mood to hand over any presents and with their top four standing now on the brink, the Foxes will know this is a game where they cannot drop any points.
Prediction: Bournemouth 1-2 Leicester
Manchester United vs Southampton
Manchester United's march continues and with their unbeaten run being extended to 10 Premier League matches, the Red Devils are certainly applying pressure on both Chelsea and Leicester, in the hope that one of them eventually slips up.
They will also look to make it five wins in a row on Monday night, as Southampton make the long journey to Old Trafford and come full time, it could be a rather long journey home as well.
Prediction: Manchester United 3-1 Southampton