Crystal Palace vs Chelsea
The action comes thick and fast and with no rest for the Premier League's wicked, we get a new gameweek underway in South London as Crystal Palace play host to Chelsea and it is fair to say that the hosts have little to play for.
Which will undoubtedly be music to the ears of Frank Lampard's men and after getting the better of Watford on Saturday, they will look to further solidify their current top four standing.
Prediction: Crystal Palace 0-2 Chelsea
Watford vs Norwich
After that defeat at Stamford Bridge, things are still looking precarious for Watford and as before, Nigel Pearson's men are just about keeping their heads above the dotted line of relegation � a line they could pull further away from in midweek.
That's because, they play host to a Norwich side who have almost resigned to the fate of relegation and this means Watford could pounce and pick up an incredibly important three points.
Prediction: Watford 1-0 Norwich
Arsenal vs Leicester
Have Arsenal left it too late in the race for a European place? On the evidence of the past few matches, you would have to say perhaps not, and Mikel Arteta knows that a win in midweek, will only help the Gunners continental cause even further.
Standing in their way, are a Leicester side who finally returned to winning ways on Saturday and after making light work of Crystal Palace, a trip to North London will prove a sterner test.
Prediction: Arsenal 1-1 Leicester
Manchester City vs Newcastle United
Pep Guardiola rung the changes on Sunday night, and you would have to say it was a decision that backfired, as the now former Premier League champions fell to a 1-0 defeat away at Southampton. A defeat that in the grand scheme of things does little to alter City's season.
In midweek, they play host to a Newcastle side who have defied the critics and now the pursuit for the Magpies will be a top half finish, one that hopefully keeps Steve Bruce in a job for a lot longer.
Prediction: Manchester City 2-0 Newcastle
Sheffield United vs Wolves
It's getting mightily congested in mid-table and after earning four points from the last six on offer, Sheffield United have just given their fading Europa League hopes a boost � a boost they'll need as Wolves make the visit to Bramall Lane this Wednesday.
Nuno Espirito Santo's men saw their impressive unbeaten run come to an end on Saturday and defeat to Arsenal has just seen their bid for a Champions League place now derail.
Prediction: Sheffield United 1-2 Wolves
West Ham vs Burnley
It's been quite the week for David Moyes's men and after picking up four points from their last six on offer, the Hammers have taken a massive stride towards survival. Now though, the challenge is to take a giant leap away from the bottom three.
To do so, they will also need to get the better of a Burnley side who have also picked up four points from six and Sean Dyche's men will now look for as strong an end to the season as possible.
Prediction: West Ham 1-1 Burnley
Brighton vs Liverpool
While although not mathematically safe, Brighton know that it is very much job done and after Leandro Trossard's winner over Norwich on Saturday, the Seagulls find themselves with a nine-point buffer between themselves and the relegation zone.
A buffer they'll need when you look at Wednesday's opposition and although champions Liverpool weren't magic at the weekend, they still had enough in the tank to get the better of Aston Villa.
Prediction: Brighton 0-2 Liverpool
Bournemouth vs Tottenham
Things really are turning sour for Bournemouth and with no win in their last eight league outings, the usual cheeky grin of manager Eddie Howe, has turned into a frown and the look of a man, who is quickly running out of ideas.
Thankfully Dr. Tottenham will be there to save the day and if you ever need a point or three, the North Londoners are more than happy to offer their expertise and cure your ailments.
Prediction: Bournemouth 1-1 Tottenham
Everton vs Southampton
There's no doubt that the capture of Carlo Ancelotti as manager was nothing short of a masterstroke and although Everton have perhaps left it too late to challenge for Europe, the blue half of Merseyside look in incredibly good stead for next season.
Thursday sees them play host to a Southampton side who are a fresh off a win over Manchester City and the Saints will look to offer another spirited performance in the next few days.
Prediction: Everton 2-1 Southampton
Aston Villa vs Manchester United
Dean Smith's men certainly looked better against Liverpool, but it was the same old story in the end and one that sees Villa's defensive deficiencies ultimately becoming their undoing � a defence that is conceding 1.87 goals per Premier League game this season.
Which means Manchester United will be licking their lips at the prospect of a Villa Park trip on Thursday and especially, as they travel off the back of a nine-league game unbeaten streak.
Prediction: Aston Villa 0-2 Manchester United