Liverpool vs Bournemouth
That's it, the monster unbeaten run from Liverpool has finally come to an end and it means that although Jurgen Klopp's men will go on and win a first ever Premier League title, they won't be able to be call themselves invincible.
This Saturday sees them go up against Bournemouth at Anfield and with the Cherries earning a point against Chelsea last weekend, Eddie Howe will have to hope his players aren't punished by the potentially resurgent hosts.
Prediction: Liverpool 2-0 Bournemouth
Arsenal vs West Ham
Arsenal were inactive last weekend, although they did manage to book a place in the F.A. Cup Quarterfinals on Monday night and with their recent positive momentum continuing, manager Mikel Arteta will look for more of the same this weekend.
The Gunners play host to local rivals West Ham and with David Moyes' men picking up an all-important win over Southampton last Saturday, the hope is that they've finally turned the corner.
Prediction: Arsenal 3-1 West Ham
Sheffield United vs Norwich
Sheffield United were another team who were inactive last weekend and because of that and a combination of other results, the Blades now find themselves playing catch up as far as the race for European places goes.
This Saturday sees them play host to a Norwich side, who have given themselves the faintest hopes of survival after getting the better of Leicester last Friday. However, Daniel Farke knows his players must deliver a few more of those performances in order to avoid relegation.
Prediction: Sheffield United 1-0 Norwich
Southampton vs Newcastle
Southampton were outclassed by West Ham last weekend and it was a performance that had Ralph Hasenhuttl lamenting the efforts of his players come the final whistle. While due to that defeat, the Saints are not safe from the threat of relegation just yet.
This weekend sees them play host to a Newcaastle side who have not scored in any of their last four league outing and if this trend continues, things could turn out to be very bleak for Steve Bruce and his players.
Prediction: Southampton 2-0 Newcastle
Wolves vs Brighton
After earning eight points from the last twelve on offer, Wolves have given themselves a genuine chance of reaching the Champions League via a top four finish and right now it seems as if Nuno Espirito Santo's men have found the bite that made Wolves so deadly last season.
They will look to continue their run of results against a Brighton side who have failed to win a league game since the turn of the year and suddenly, the Seagulls are nervously looking over their shoulder.
Prediction: Wolves 2-0 Brighton
Crystal Palace vs Watford
Back to back league wins for Crystal Palace has almost assured them of another stint in the Premier League next season and with their current points tally, you get the feeling that one more victory will finally get them over the line.
This Saturday sees them play host to a Watford side who will be flying high after such an impressive win over Liverpool, although the mood will be tempered by the news that Gerard Deloufeu is out for the rest of the season.
Prediction: Crystal Palace 1-1 Watford
Burnley vs Tottenham
Burnley are one of the form teams in the Premier League at present and with them avoiding defeat in their last six outings, Sean Dyche will have to decide just how ambitious he and his players want to be and whether another Euro jolly is worth domestic upheaval.
If it is, then they will have Tottenham firmly in their sights and with the North Londoners' season crumbling before them, things could get a lot worse before they get better under Jose Mourinho.
Prediction: Burnley 2-1 Tottenham
Chelsea vs Everton
Chelsea may have left the top four door ajar last weekend, but from their point of view no-one managed to prise it open and that means the Stamford Bridge outfit are still in the box seat when it comes to the race for fourth place.
They go up against an Everton side who will consider themselves unfortunate not to have got the better of Manchester United last Sunday, in a game where Carlo Ancelotti was given his marching orders after the final whistle.
Prediction: Chelsea 2-1 Everton
Manchester United vs Manchester City
Manchester United look resurgent as of late and the signing of Bruno Fernandes has been nothing short of a masterstroke, with the Portuguese midfielder reigniting the Red Devils hopes of pipping Chelsea to a fourth-place finish.
This Sunday, they will look to not only earn three points but also earn local bragging rights, as they play host to a Manchester City side that recorded a third straight Carabao Cup Final success last weekend.
Prediction: Manchester United 1-2 Manchester City
Leicester vs Aston Villa
Leicester have failed to win any of their last four league outings and although they were almost locked on for a third place finish a month or so ago, a return to Champions League football is no longer a guarantee for the Foxes.
They will look to kickstart their campaign against an Aston Villa side who were edged out by Manchester City at Wembley and although they suffered defeat, manager Dean Smith will be able to take solace from the performance.
Prediction: Leicester 1-1 Aston Villa